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    Antimicrobial susceptibility patterns of bacterial isolated from urinary tract infection among patients under chemotherapy and non chemotherapy in Khartoum state Sudan “2021
    (Napata College, 2021) Husam Eldien Kamal Hamad Mohamed; Ahmed Manaa Badawi Omer; Mahir Awad Yassin Diaeldean,; Sufian Ali Abubaker Ishag; Mohamed El nibras Abdallah billal; Sambo Alim Sambo Khaundi; Mohammed Allalah Mohammed; Ahmed Ahmed Abdullah Ahmed
    Background Urinary tract infections are the common types of infections in the community and health care settings. Despite the widespread availability of antibiotics, urinary tract infection remains a worldwide therapeutic problem. It is a continuous and significant problem in cancer patients. Methods A hospital-based comparative cross-sectional study was conducted on 100 study participants from August to October 2021. Sociodemographic data were collected by a predesigned questionnaire and midstream urine samples collected using simple random sampling technique by using clean, sterile plastic cups and then inoculated onto CLED agar plates and incubated at 37°C for 24 hours. Urine culture was considered significant bacteriuria when colony forming units ≥105/mL of voided urine. Identification was done by using standard microbiological methods. Modified Kirby–Bauer disk diffusion technique was applied for antimicrobial susceptibility testing in accordance with CLSI 2018 criteria. Data were entered, cleared, checked and exported to SPSS version 20 for analysis. The results were displayed using tables and figures. Value <0.05 at 95% CI was considered as statistically significant. Results The overall prevalence of asymptomatic bacteriuria in cancer patients was 56% and 44% of samples did not grow in media. Staphylococcus aureus (20%) was the commonest isolated uropathogenic bacteria followed by E. coli (18%), Candida albicans (10%), Pseudomonas argionosa (4%), Enterococcus fecalis (2%) and Klebsiella species (2%), in cancer patients. Conclusions This study showed a high prevalence of asymptomatic bacteriuria among cancer patients (56%) compared to apparently healthy donors (44%). E. coli was isolated predominately.
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    Detection of Beta-lactamase TEM gene in Escherichia coli Isolates Collected from Urine Samples in Khartoum State – Sudan
    (Napata College, 2021) Alaa Shamsaldeen Alboshary Ahmed; Ghofran Ibraheem Ahmed Hasan; Jenan Mohammed Adam Altaher; Laila Salah Mohammed Taha; Nawader Alamamoon Abualtayib Alnoor; Nazik Malik Ibraheem Saeed; Sadia Zakarya Trebo Osman; Tibyan Hasabalrasool Altayib Hasan
    Escherichia coli are the most common cause of urinary tract infections worldwide and they are the fourth leading cause of health care associated infections. The objective of this study was detection of Beta-lactamase TEM gene in Escherichia coli Isolates Collected from Urine Samples in Khartoum State – Sudan. A total of 96 of Escherichia coli were isolated from different hospitals in Khartoum State. The present study showed that the percentage of infection in females (64/96) (66.7%) were more than the percentage of infection in males (32/96) (33.3%). There was high prevalence rate of Escherichia coli urinary tract infection within the age group (25-44) (35.4%). Out of 96 isolated Escherichia coli 76(79.2%) were positive for TEM gene. Further studies with large number of samples and more advanced techniques are required to validate the results of the present study.