Issue 1

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Browsing Issue 1 by Author "Hatil Hashim EL-Kamali"

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    Comparison of the Chemical Composition of Ambrosia maritima Collected from Two Different Locations in Ed-Damer region, River Nile State, North Sudan Based on GC/MS Analysis
    (Napata College, 2024-04) Khalid Elshafie Osman Elshafie; Ibrahim Saeed Yousef; Hatil Hashim EL-Kamali
    In this study, Gas Chromatography-Mass Spectrometry (GC-MS) was used to compare the chemical compositions of Ambrosia maritima aerial parts collected from two different locations in Ed-Damer region, River Nile State, Northern Sudan. The results showed that 14 compounds of the two plant samples contained the same chemical composition, which was 2-methoxy-4-vinyl phenol, Decanoic acid ethyl ether, 1-cyclohexene 1-ol, 2,6- dimethyl acetate, 2-acetoxy 1,1,10 trimethyl 6,9-epidioxydecalin, 6,8-nonadien-2-one, 6- methyl-5-(1-methylethylidene-, Ethyl alpha-d-glucopyranoside, Hexadecanoic acid, methyl ester, n-Hexadecanoic acid, Hexadecanoic acid, ethyl ester, Phytol, Androstan-17- one,3-ethyl-3-hydroxy (5-alpha), 17-beta-hydroxy-6-oxo-4,5-secoandrosta-, 5-alpha-17- alpha pregnan-12 one and Cyclohexanamine,N-(hexa-hydro-3 methylene 2(3H) – Comp. of Chem. Composition of A. maritima Elshafie et. al. benzofuranyledene)-but the percentage content was different. The main components of the ethanolic extracts of the two samples were different. N,N-dimethylglycine (2.16%) , Norethindrone (19.76%), alpha-amyrin (0.66%) and others were only detected in Ambrosia maritima (sample Am1), Nitroacetamine (16.07%) , linoleic acid, ethyl ester (9.83%), gamma-sitosterol (5.59%), and others were only detected in Ambrosia maritima (sample Am2).
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    Evaluation of Haematological and Biochemical Parameters of Aqueous Seed Extract of Solenostemma argel in Male Albino Rats
    (Napata College, 2024-04) Nagia Khallafala Atta EL-Fadeel; Hatil Hashim EL-Kamali; Azam Abdel Aal Afifi; Sara Hamad
    The present study was conducted to evaluate the toxicity/safety potential of Solenostemma argel seeds aqueous extract at three different doses (700, 500 and 200 mg/Kg b.w) in albino rats using haematological and biomedical parameters. Male albino rats were used in this study; the rats were divided into four groups. The blood parameters measured were: WBC, RBC, HGB, HCT, MCV, MCH, MCHC, Lym %, Gran %, Mid %, Lym #, Gran #, Mid #, PLT, MPV, PDW, PCT, P.LCR, P.LCC , RDW-CV and RDW-SD, whereas the biochemical parameters measured were : AST, ALP, ALP, Glucose , total cholesterol and triglycerides. Our study finding demonstrated that aqueous extract of S.argel seed at doses 700 and 500 mg/Kg b.w caused reductions in MCV, Gran %, Gran #, PCT, PLT, P-LCC and RDW-SD, whereas at dose 200 mg/Kg b.w caused reductions in PLT, PCT and PLCC. The extract caused increase in WBC (except at 700 mg/Kg b.w), HGB, HCT, Lym%, PDW, P-LCR, Lym # (except at dose 700 mg/Kg b.w). The rats groups at three doses showed non-significant change in liver function tests parameters (AST,ALT and ALP), whereas as it showed significant change in Glucose, triglycerides and total cholesterol (except at dose 200 and 500 mg/Kg b.w. Consumption of this plant may have tremendous impact on subjects suffering from hyper-triglyceridermia. This supports the safety use of the aqueous extract of S.argel in pharmacological studies.