Evaluation of Haematological and Biochemical Parameters of Aqueous Seed Extract of Solenostemma argel in Male Albino Rats
Evaluation of Haematological and Biochemical Parameters of Aqueous Seed Extract of Solenostemma argel in Male Albino Rats
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Date
2024-04
Authors
Nagia Khallafala Atta EL-Fadeel
Hatil Hashim EL-Kamali
Azam Abdel Aal Afifi
Sara Hamad
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Journal ISSN
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Publisher
Napata College
Abstract
The present study was conducted to evaluate the toxicity/safety potential of Solenostemma
argel seeds aqueous extract at three different doses (700, 500 and 200 mg/Kg b.w) in albino
rats using haematological and biomedical parameters. Male albino rats were used in this
study; the rats were divided into four groups. The blood parameters measured were: WBC,
RBC, HGB, HCT, MCV, MCH, MCHC, Lym %, Gran %, Mid %, Lym #, Gran #, Mid #,
PLT, MPV, PDW, PCT, P.LCR, P.LCC , RDW-CV and RDW-SD, whereas the
biochemical parameters measured were : AST, ALP, ALP, Glucose , total cholesterol and
triglycerides. Our study finding demonstrated that aqueous extract of S.argel seed at doses 700 and 500 mg/Kg b.w caused reductions in MCV, Gran %, Gran #, PCT, PLT, P-LCC
and RDW-SD, whereas at dose 200 mg/Kg b.w caused reductions in PLT, PCT and PLCC. The extract caused increase in WBC (except at 700 mg/Kg b.w), HGB, HCT, Lym%,
PDW, P-LCR, Lym # (except at dose 700 mg/Kg b.w). The rats groups at three doses
showed non-significant change in liver function tests parameters (AST,ALT and ALP),
whereas as it showed significant change in Glucose, triglycerides and total cholesterol
(except at dose 200 and 500 mg/Kg b.w. Consumption of this plant may have tremendous
impact on subjects suffering from hyper-triglyceridermia. This supports the safety use of
the aqueous extract of S.argel in pharmacological studies.
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