Evaluation of Haematological and Biochemical Parameters of Aqueous Seed Extract of Solenostemma argel in Male Albino Rats

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dc.contributor.authorNagia Khallafala Atta EL-Fadeel
dc.contributor.authorHatil Hashim EL-Kamali
dc.contributor.authorAzam Abdel Aal Afifi
dc.contributor.authorSara Hamad
dc.date.accessioned2025-09-19T10:41:10Z
dc.date.available2025-09-19T10:41:10Z
dc.date.issued2024-04
dc.descriptionOriginal article
dc.description.abstractThe present study was conducted to evaluate the toxicity/safety potential of Solenostemma argel seeds aqueous extract at three different doses (700, 500 and 200 mg/Kg b.w) in albino rats using haematological and biomedical parameters. Male albino rats were used in this study; the rats were divided into four groups. The blood parameters measured were: WBC, RBC, HGB, HCT, MCV, MCH, MCHC, Lym %, Gran %, Mid %, Lym #, Gran #, Mid #, PLT, MPV, PDW, PCT, P.LCR, P.LCC , RDW-CV and RDW-SD, whereas the biochemical parameters measured were : AST, ALP, ALP, Glucose , total cholesterol and triglycerides. Our study finding demonstrated that aqueous extract of S.argel seed at doses 700 and 500 mg/Kg b.w caused reductions in MCV, Gran %, Gran #, PCT, PLT, P-LCC and RDW-SD, whereas at dose 200 mg/Kg b.w caused reductions in PLT, PCT and PLCC. The extract caused increase in WBC (except at 700 mg/Kg b.w), HGB, HCT, Lym%, PDW, P-LCR, Lym # (except at dose 700 mg/Kg b.w). The rats groups at three doses showed non-significant change in liver function tests parameters (AST,ALT and ALP), whereas as it showed significant change in Glucose, triglycerides and total cholesterol (except at dose 200 and 500 mg/Kg b.w. Consumption of this plant may have tremendous impact on subjects suffering from hyper-triglyceridermia. This supports the safety use of the aqueous extract of S.argel in pharmacological studies.
dc.description.sponsorshipNapata College
dc.identifier.issn2948-300X
dc.identifier.issn2948-3018
dc.identifier.otherDOI = https://doi.org/10.53796/nsj31/2
dc.identifier.urihttp://dspace.napata.edu.sd/handle/123456789/353
dc.language.isoen
dc.publisherNapata College
dc.titleEvaluation of Haematological and Biochemical Parameters of Aqueous Seed Extract of Solenostemma argel in Male Albino Rats
dc.typeArticle
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