Association of Serum Lipid Profile Levels in Chronic Kidney Disease Patients with Cardiovascular Disease a case control study, Khartoum State

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Mohammed M.A
Mohammed I.A
Ismail A.M
Ali A.M
Dafaalla M.H
Mohammed R.K
Edris S.M
Ali S.Y
Nourallah S.A
Abdalla I.A
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Napata College
Background: The burden of chronic kidney disease (CKD) is increasing rapidly worldwide and has become a major health problem and most of these patients die due to cardiovascular disease (CVD) before progression to end stage renal disease (ESRD). Therefore, poor cardiovascular outcomes in CKD patients have prompted nephrologists to look for biomarkers that may improve risk stratification in this population. The objective of this study was to evaluate serum lipid profile levels in CKD patients and to determine their association with cardiovascular diseases. Materials & Methods: This analytical case control study was conducted at Ibnsina and Military hospitals in the period from February 2016 to March 2019, (n = 150) clinically diagnosed CKD patients (age range between 22 - 76 years, 105 males and 45 females), and 150 healthy subjects were included as controls. Serum lipid profile and serum creatinine were estimated by Cobas C-311® fully automated analyzer, hemoglobin by Sysmix, glomerular filtration rate (GFR) was calculated by Cocroft-Gault formula and blood pressure was measured by using mercuric sphygmomanometer. Results:The results of the current study indicated that, the means of total cholesterol, triglyceride, LDL-C, creatinine, systolic blood pressure (SBP), diastolic blood pressure (DBP) and body mass index (BMI) were significantly (P-value ≤0.05) higher in CKD patients when compared with that of controls, while HDL-C, hemoglobin and GFR were significantly (P-value ≤0.05) lower. Moreover, serum SBP and DBP were significantly (P-value ≤0.05) higher in CKD patients with cardiovascular disease (CVD) than CKD patients without CVD, while the means of cholesterol, TG, LDL-C, BMI and creatinine were insignificantly (P-value ˃0.05) increased, meanwhile the mean of HDL-C, GFR and hemoglobin were insignificantly (P-value ˃0.05) decreased. In addition there is insignificant increase in the means of TG, LDL-C, BMI, SBP, DBP, creatinine and hemoglobin, and insignificant decrease in the mean of cholesterol, HDL-C and GFR in male when compared with female in CKD patients. Conclusion:dyslipidemia (high levels of cholesterol, TG, LDL-C and low levels of HDL-C) was higher in patients with CKD. Thus, the lipid profile levels were strongly associated with cardiovascular events in patients who have CKD and are on maintenance hemodialysis (HD).