Issue 1

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Browsing Issue 1 by Author "Nagia Khallafala Atta EL-Fadeel"

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    Evaluation of Haematological and Biochemical Parameters of Aqueous Seed Extract of Solenostemma argel in Male Albino Rats
    (Napata College, 2024-04) Nagia Khallafala Atta EL-Fadeel; Hatil Hashim EL-Kamali; Azam Abdel Aal Afifi; Sara Hamad
    The present study was conducted to evaluate the toxicity/safety potential of Solenostemma argel seeds aqueous extract at three different doses (700, 500 and 200 mg/Kg b.w) in albino rats using haematological and biomedical parameters. Male albino rats were used in this study; the rats were divided into four groups. The blood parameters measured were: WBC, RBC, HGB, HCT, MCV, MCH, MCHC, Lym %, Gran %, Mid %, Lym #, Gran #, Mid #, PLT, MPV, PDW, PCT, P.LCR, P.LCC , RDW-CV and RDW-SD, whereas the biochemical parameters measured were : AST, ALP, ALP, Glucose , total cholesterol and triglycerides. Our study finding demonstrated that aqueous extract of S.argel seed at doses 700 and 500 mg/Kg b.w caused reductions in MCV, Gran %, Gran #, PCT, PLT, P-LCC and RDW-SD, whereas at dose 200 mg/Kg b.w caused reductions in PLT, PCT and PLCC. The extract caused increase in WBC (except at 700 mg/Kg b.w), HGB, HCT, Lym%, PDW, P-LCR, Lym # (except at dose 700 mg/Kg b.w). The rats groups at three doses showed non-significant change in liver function tests parameters (AST,ALT and ALP), whereas as it showed significant change in Glucose, triglycerides and total cholesterol (except at dose 200 and 500 mg/Kg b.w. Consumption of this plant may have tremendous impact on subjects suffering from hyper-triglyceridermia. This supports the safety use of the aqueous extract of S.argel in pharmacological studies.