MEASUREMENT OF COAGULATION PARAMETERS & D-DIMER AMONG SUDANESE PREGNANT WOMEN WITH PREECLAMPSIA IN KHARTOUM STATE IN 2022.
MEASUREMENT OF COAGULATION PARAMETERS & D-DIMER AMONG SUDANESE PREGNANT WOMEN WITH PREECLAMPSIA IN KHARTOUM STATE IN 2022.
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Date
2022
Authors
Abdalrhman Adam Suliman Adam
Abdalla Sayed Hamid Hamed
Ahmed Ibrahim Khalil Mohamed
Rashed Ahmed Khalafallah Ali
Journal Title
Journal ISSN
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Publisher
Napata College
Abstract
Background: Preeclampsia affects 5%–7% of all pregnancies globally and is the
leading cause of maternal and fetal death and morbidity. The mechanisms
responsible for the pathogenesis of preeclampsia are unclear. In this study we
aimed to measure coagulation parameters and D-dimer level among Sudanese
pregnant women with Preeclampsia.
Patients and Methods: case control hospital-based study Conducted at
Omdurman Military Hospital. Khartoum, Sudan, study include two groups s ixty
were women healthy twenty and group Cases were eclampsia -pre with women
and questionnaire, interviewing direct using collected data ،control as included
were D.dimer and INR APTT, PT, patients. all from collected was sample blood
.(26 vs) programe ware soft SPSS using analyzed Data assessed.
Results: out of total over one third 31 (38.8%) of patients within age group 20-30
years, followed by 22(28.3%) within age group 31-40 years. No significant
difference in age group between cases and controls. According to parity, 23(38.3
%) of cases were Primigravida, 20(33.3%) were multipara, and 17(28.3%) were
Grand multipara. Compared to control group 12(60%) of control group were
multipara. (P value= 0.00). There was significant difference in mean PT (cases
23.34±21.4, vs controls control:18.99±1.37), (P value=0.036). INR was
significantly higher among cases group (1.17±0.18 vs 1.10±0.10), (P value =0.00).
D. dimer was significantly higher among cases (mean±SD) (5595.4 ±2442.0 vs
3240.6± 724.6). There was Statistically insignificant differences in PT, APTT, and
INR according to preeclampsia severity. (P value>0.05). D. dimer significantly
incresed with severity of preeclampsia (P value =0.041).
Conclusion: Prothrombin time, INR, and D. dimer were significantly higher
among preeclampsia group, and increased with preeclampsia severity.