Polyvinylpyrrolidone Superdisintegrant: The Effect of Mode of Incorporation on Disintegration Time in Both Wet and Dry Granulated Tablets
Polyvinylpyrrolidone Superdisintegrant: The Effect of Mode of Incorporation on Disintegration Time in Both Wet and Dry Granulated Tablets
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Date
2023
Authors
Mona Alshareef Almiski
Marwa Sami Mohammed
Fatima Mohammed Ali
Shadia Abdallah Izzeldin
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Publisher
Napata College
Abstract
Introduction: Superdisintegrats are used in tablets and capsules to ensure
a faster breakdown into their primary particles facilitating the dissolution
and release of active pharmaceutical ingredients.
Objective: To estimate the effect of PVP as superdisintegrant and its
mode of incorporation on the disintegration time for both wet and dry
granulated tablets. To decide which granulation method and
incorporation mode is the best in decreasing disintegration time.
Method: for both wet and dry granulated tablets formtion, three batches
of placebo tablets were formulated for each. The PVP superdisintegrant
were incorporated extragranulary, intragranulary and partly intraextragranulary.
Then, formulations were compressed and tablets were
subjected to disintegration time test.
Results and conclusion: the results indicate that PVP exerts a great
influence in tablets disintegration time when incorporated as
superdisintegrant in wet granulated tablets. The partly intraextragranular
mode achieved the best disintegration time in comparison
to other modes
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Napata College