Immunochemotherapy of persistent post-kala-azar dermal leishmaniasis: a novel approach to treatment

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dc.contributor.authorAhmed Mudawi Musa
dc.contributor.authorEltahir Awad Gasim Khalil
dc.contributor.authorFawzi Abd Elrahim Mahgoub
dc.contributor.authorSara Hamad Hassab Elgawi
dc.contributor.authorFarroukh Modabber
dc.contributor.authorAbd Elgadir Mohamed Yousif Elkadaru
dc.contributor.authorMona Hussein Aboud
dc.contributor.authorSassan Noazin
dc.contributor.authorHashim Warsma Ghalib
dc.contributor.authorAhmed Mohamed El-Hassan
dc.date.accessioned2023-01-12T11:16:31Z
dc.date.available2023-01-12T11:16:31Z
dc.date.issued2007
dc.description.abstractPost-kala-azar dermal leishmaniasis (PKDL) is a recognized dermatosis that follows successful treatment of visceral leishmaniasis in the Sudan. This randomized and doubleblind study aimed to assess safety, immunogenicity and curative potentials of a novel immunochemotherapy regimen in patients with persistent PKDL. Following informed consent, 30 patients were randomized to receive alum-precipitated autoclaved Leishmania major (Alum/ALM) vaccine + Bacille Calmette-Gu´erin (BCG) and sodium stibogluconate (SSG) or vaccine diluent and SSG. The SSG+Alum/ALM+BCG proved safe with minimal local adverse events. In the SSG+vaccine group, 87% of the patients were cured by day 60 compared with 53% in the SSG alone group (SSG+vaccine efficacy = 71%, 95% CI for risk ratio 0.7—1.16). On day 90 of follow-up there were two relapses in the SSG alone arm and none in the SSG+vaccine arm. Pretreatment cytokines showed high IFN- or high IFN- /IL-10 levels and leishmanin skin test (LST) non-reactivity, while healing/clinical improvement were associated with LST reactivity and low
dc.identifier.citationMusa, A.M., Khalil, E.A.G., Mahgoub, F.A.E., Elgawi, S.H.H., Modabber, F., Elkadaru, A.E.M.Y., Aboud, M.H., Noazin, S., Ghalib, H.W. and El-Hassan, A.M., 2008. Immunochemotherapy of persistent post-kala-azar dermal leishmaniasis: a novel approach to treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102(1), pp.58-63.
dc.identifier.issn00359203
dc.identifier.urihttp://dspace.napata.edu.sd/handle/123456789/210
dc.language.isoen
dc.publisherElsevier
dc.titleImmunochemotherapy of persistent post-kala-azar dermal leishmaniasis: a novel approach to treatment
dc.typeArticle
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