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Immunoexpression of Vascular Endothelial Growth Factor among Sudanese Patients with Bladder Cancer
(International Journal of Academic Health and Medical Research, 2021-09) Changjowk Peter Lai AKER; Mohammed Abdelgader Elsheikh MOHAMMED; Elsadig Ahmed ADAM; Alkhair Abd Almahmoud Idris
Vascular endothelial growth factor (VEGF) is a signaling protein which is important for formation of the circulatory system and growth of blood vessels from pre-existing vasculature. Cancers that can express VEGF are able to grow and metastasize, because many solid cancers require an adequate blood supply to grow beyond the limited size. Aim: To determine the Immunoexpression of Vascular Endothelial Growth Factor among Sudanese Patients with Bladder Cancer. METHODOLOGY: This was an analytical cross-sectional study, included forty patients with (TCC); study patients from different Histopathology laboratories in Khartoum state- Sudan, VEGF was detected by using IHC method. RESULTS: VEGF immunoexpression was reported positive in 20 out of 40 patients (50%), the study conducted that; there was an association of VEGF immunoexpression and higher tumor grade of (TCC) as the frequency of VEGF expression was 16 out of 27 patients (59.2%) with high grade, while the frequency of VEGF expression was 4 out of 13 patients of low grade (30.8%) P value = 0.010. CONCLUSSION: according to obtained results we concluded that; the, there was a significant association between VEGF and bad prognosis of (TCC).