Some Metabolic and Organ Function Disturbances Related to Thyroid Dysfunction
Some Metabolic and Organ Function Disturbances Related to Thyroid Dysfunction
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Date
2025-04
Authors
Abdelgayoum Ahmed Abdel-Gayoum
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Publisher
Napata College
Abstract
Background: Hypothyroidism and hyperthyroidism are the thyroid disorders that involve
adverse metabolic disturbances. The present study aims to investigate the serum lipid profile,
glucose levels and the renal function in newly diagnosed hypothyroid (HO) and hyperthyroid
(HE) patients.
Methods: This cross-sectional study was carried out in King Khaled hospital, Hail, Saudi
Arabia. The database of 72 (M=17, F=55) newly diagnosed patients with thyroid disfunction
were included in the study. Based on their thyroid stimulating hormone (TSH) results, the
patients were classified into HO (TSH ≥ 4.5 mIU/L), HE (TSH ≤ 0.4 mIU/L) and normal
subjects used as control. The levels of serum free triiodothyronine (FT3), free thyroxine (FT4),
TSH, serum total cholesterol (TC), triglycerides (TGs), HDL, LDL, glucose, creatinine, blood
urea nitrogen (BUN) and uric acid (UA) were assayed in the hospital laboratory. and VLDL
calculated by subtraction.
Results: The serum glucose levels were significantly elevated in the HE (P < 0.01) and HO (P <
0.05) groups compared to control, with significant positive correlation with Log FT4. Whereas, the serum TCs of the HO group was significantly (P < 0.05) higher than the HE, but not
different from control. Similarly, the serum TGs level of the HE group was significantly lower
than control (P < 0.05) and HO (P < 0.01) groups. However, the HDL- and LDL-cholesterol
fractions were not significantly altered in any of the groups. The VLDL- fraction of the HE
group was significantly (P < 0.05) lower than the control, and was lower than the HO group (P
< 0.01). The TSH showed significant positive correlations with TC and TGs. The serum
creatinine in the HE group was significantly (P < 0.01) lower than control and significantly (P <
0.001) lower than the HO. Similarly, the serum BUN and UA in the HO group were
significantly (P < 0.05) higher than the HE. Moreover, the TSH exhibited significant positive
correlations with serum creatinine and UA. Whereas, the FT4 and FT3 exhibited negative
correlations with creatinine.
Conclusion: The existence of insulin resistance in both HO and HE was evidenced by the
significantly elevated serum glucose concentrations, whereas, the TC and TGs were
significantly elevated in the HO group and reduced in the HE. The renal impairment was
confirmed by the elevated renal function markers in the HO, but unaltered in the HE.
We recommend that during treating patients with thyroid disfunction, such related metabolic
disturbances should be considered and treated to avoid further progression into chronic
complications.
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Original article